Display omitted •Low salinity waterflooding (LSW) in secondary mode boots production rate and recovery.•Multi-component ionic exchange (MIE) is the mechanism causing wettability reversal.•LSW triggers the removal of Ca 2+and Mg2+ links from the sand surface making it water wet. Low salinity waterflooding (LSW) is a promising enhanced oil recovery process. The LSW advantage has been associated to changes in rock wettability toward a more water wet state. This study evaluated the effect of different flooding schemes on the performance of LSW in terms of production rate and incremental oil recovery from sand-pack systems. This work also investigated the main mechanism prompting sand wettability changes during LSW. Flooding Scheme-1 consisted of high salinity waterflooding, low salinity waterflooding, alkali aided low salinity waterflooding, and low salinity waterflooding. Flooding Scheme-2 consisted of low salinity waterflooding, alkali aided low salinity waterflooding, and low salinity waterflooding. Flooding Scheme-3 consisted of alkali aided low salinity flooding and low salinity waterflooding. The main mechanism causing wettability reversal was verified employing contact angle analysis, inductively coupled plasma spectrometry, and scanning electron microscopy. This new study reveals in a straightforward manner the effect of low salinity waterflooding schemes on both production rate and incremental oil recovery. LSW in secondary mode, as conducted in FS-2, expedited the oil production rate by 15% and increased the overall oil recovery by 20% relative to flooding schemes FS-1 and FS-3. Furthermore, this study determined that multi-component ionic exchange was the dominant mechanism for the reversal of sand wettability to a more water wet state. This paper provides new insights for heavy oil producers on the relevance of the flooding schemes during LSW and on the dominant mechanism for wettability alteration during the recovery of heavy oil from unconsolidated sands.