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  • Strong associations and mod...
    Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020
    Tostmann, Alma; Bradley, John; Bousema, Teun; Yiek, Wing-Kee; Holwerda, Minke; Bleeker-Rovers, Chantal; Ten Oever, Jaap; Meijer, Corianne; Rahamat-Langendoen, Janette; Hopman, Joost; van der Geest-Blankert, Nannet; Wertheim, Heiman

    Euro surveillance : bulletin européen sur les maladies transmissibles, 04/2020, Letnik: 25, Številka: 16
    Journal Article

    Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.

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