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Huang, Chun-Jung; Slusher, Aaron L.; Whitehurst, Michael; Wells, Marie; Mock, J. Thomas; Maharaj, Arun; Shibata, Yoshimi
Life sciences (1973), 08/2015, Letnik: 135Journal Article
G protein-coupled receptor kinase 2 (GRK2), a cytosolic enzyme desensitizing G protein-couple receptors (e.g., β-adrenergic receptors β-ARs), is involved in regulation of hypertension, congestive heart failure, and inflammatory response. Since cellular GRK2 levels change quickly in response to exogenous/endogenous stimuli, this study examined whether GRK2 levels in human peripheral blood mononuclear cells (PBMCs) would increase during acute aerobic exercise and be associated with plasma IL-6 and cardiorespiratory fitness levels. Eighteen subjects (8 men and 10 women), ages 18 to 30years, were recruited to perform a 30-minute bout of acute aerobic exercise at 75% VO2max. Our results demonstrated that women exhibited significantly greater exercise-induced GRK2 expression in PBMCs compared to men. IL-6 modulation is independent of GRK2 expression. Furthermore, the percent change in GRK2 expression was negatively correlated with cardiorespiratory fitness levels (relative VO2max), but not plasma IL-6. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs. Gender could be a contributor to regulate this GRK2 responsiveness to acute aerobic exercise.
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in: SICRIS
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