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Lv, Yueying; Jiang, Huijie; Li, Siyu; Han, Bing; Liu, Yan; Yang, Daqian; Li, Jiayi; Yang, Qingyue; Wu, Pengfei; Zhang, Zhigang
Environmental pollution (1987), April 2020, 2020-Apr, 2020-04-00, Letnik: 259Journal Article
Chromium (Cr) is an internationally recognized carcinogenic hazard that causes serious pulmonary toxicity. However, Cr-induced pulmonary toxicity lacks effective treatment to date. Sulforaphane (SFN), a well-known organosulfur compound, has gained increasing attention because of its unique biological function. This study investigates if SFN could decrease K2Cr2O7-induced pulmonary toxicity and a potential mechanism involved using a rat 35-day Cr-induced pulmonary toxicity model and the mouse alveolar type II epithelial cell line (MLE-12). The results showed that SFN prevented Cr-induced oxidative stress, histopathological lesions, inflammation, apoptosis, and changes in protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3β) levels in vivo and in vitro. However, SFN can not play the protective effect against K2Cr2O7-induced cell injury after treating by an Akt-specific inhibitor (MK-2206 2HCl) in MLE-12 cells. Furthermore, SFN increased the expression of nuclear factor-E2-related factor-2 (Nrf2) phase II detoxification enzymes. Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3β/Fyn signaling pathway. SFN may be a novel natural substance to cure Cr-induced lung toxicity. Display omitted •Chronic exposure of chromium (Cr) induces lung injury in rats.•Cr induces oxidative stress in the mouse alveolar type II epithelial cell line.•Oxidative stress is a key of Cr-induced lung toxicity.•Sulforaphane (SFN) relieves Cr-induced lung toxicity.•SFN prevents Cr-induced lung toxicity in rats via activation of the Akt/GSK-3β/Fyn signaling pathway. Sulforaphane prevents chromium-induced lung toxicity in rats via activation of the Akt/GSK-3β/Fyn signaling pathway.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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