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Zhou, Jian; Zhang, Lei; Chen, Jinkang; Chen, Junyu; Yin, Chuanliu; Yu, Chuanming
Tetrahedron letters, 09/2020, Letnik: 61, Številka: 38Journal Article
Display omitted •Rh-catalyzed 4+1 annulation afforded pyrazolo1,2-a indazole derivatives.•Reaction occurred under mild conditions and have good functional group tolerance.•KIE experiments were conducted to explore the possible mechanism. A Rhodium(III)-catalyzed 4+1 annulation and ring opening of 1‑alkynylcyclobutanols with pyrazolidinones to access pyrazolo1,2-a indazoles bearing a quaternary carbon center was described. This method features high functional group tolerability and afforded pyrazolo1,2-a indazoles in moderate to good yield under mild conditions.
![Rh(III)-catalyzed [4+1] ann...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0040-4039/medium "Rh(III)-catalyzed [4+1] annulation and ring opening for the synthesis of pyrazolo[1,2-a] indazole bearing a quaternary carbon")
