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Le Page, Aurélie; Khalil, Abdelouahed; Vermette, Patrick; Frost, Eric H.; Larbi, Anis; Witkowski, Jacek M.; Fulop, Tamas
Matrix biology, November 2019, 2019-11-00, 20191101, Letnik: 84Journal Article
Once considered as inert, the extracellular matrix recently revealed to be biologically active. Elastin is one of the most important components of the extracellular matrix. Many vital organs including arteries, lungs and skin contain high amounts of elastin to assure their correct function. Physiologically, the organism contains a determined quantity of elastin from the early development which may remain physiologically constant due to its very long half-life and very low turnover. Taking into consideration the continuously ongoing challenges during life, there is a physiological degradation of elastin into elastin-derived peptides which is accentuated in several disease states such as obstructive pulmonary diseases, atherosclerosis and aortic aneurysm. These elastin-derived peptides have been shown to have various biological effects mediated through their interaction with their cognate receptor called elastin receptor complex eliciting several signal transduction pathways. In this review, we will describe the production and the biological effects of elastin-derived peptides in physiology and pathology. •Elastin-derived peptides via their cognate elastin-receptor complex mediate various physiological and pathological functions.•Elastin-derived peptides may be determined in the circulation.•Elastin-derived peptides play major roles in the pathomechanisms of atherosclerosis and chronic obstructive lung diseases.•Elastin-derived peptides are a potential target in the treatment of atherosclerosis and chronic obstructive lung diseases.
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