Angiogenesis is a deliberate sequence of events that starts with destabilization of an existing vascular bed, and ends when the newly generated vessels quiesce. During angiogenesis, endothelial cell growth, migration, and tube formation are regulated by pro- and anti-angiogenic factors, matrix-degrading proteases, and cell-extracellular matrix interactions. VEGF, arguably the best-studied angiomodulator, is highly regulated at the levels of synthesis, spatial distribution, receptor and co-receptor availability, and signaling downstream of the receptors. While many agents that contribute to angiogenesis have been identified and studied in depth, others, such as lysophosphatidic acid (LPA), are relatively unexplored.