Display omitted •Enhancing the properties of PCL using HAP, Ag3VO4, and Turmeric for wound healing.•The contact angle of PCL decreased from 54.56°±2.1 to 35.18°±1.6 after adding NPs.•The cell viability of HFB4 for the final film is 109 % ± 3 %.•The modified PCL showed thermal stability with a weight loss of 88.5 % at 460 °C.•The cell attachment test showed high attachment on the surface of the nanofilm. In recent times, wound healing has emerged as a multifaceted biological process, necessitating the development of innovative strategies for designing wound dressing materials with improved properties. These materials should exhibit high antibacterial activity and biocompatibility. The aim is to create wound dressings that possess ideal properties, addressing the diverse requirements of effective wound management. This study involves the fabrication of a special biodegradable scaffold made of polycaprolactone (PCL) using a straightforward and environmentally friendly process called polymer casting. The scaffold is then enhanced with hydroxyapatite (HAP) and Ag3VO4 NPs and turmeric (Tur). As illustrated in cell viability, The fabricated HAP/Ag3VO4/Tur@PCL scaffold reached a significantly high value of viable cells (109 % ± 3 %) using human fibroblast cell line, which is reflecting its great biocompatibility. Furthermore, its (TGA) analysis shows high thermal stability with a weight loss (88.5 %) at 460 ◦C, The UV–vis spectra of the HAP/Ag3VO4/Tur@PCL demonstrated that the scaffold has an extended absorption range reached (427 nm) with a narrow band gap compared to the other samples. Thus, this innovative method of modifying composites based on PCL takes into account intelligent biomedical scaffolds wound healing procedures, featuring uncomplicated designs and improved capabilities.