Spotted wing drosophila, Drosophila suzukii, is an invasive insect pest that has spread into many fruit production regions of the world. Strategies to protect fruit from infestation by this insect are currently dominated by insecticide applications, so producers need information on relative efficacy and residual activity of insecticides to be able to select effective treatments. Semi-field bioassays in which highbush blueberry shoots with berries were treated then exposed to adult flies at different times after application revealed that fresh residues of organophosphate, pyrethroid, and spinosyn insecticides have strong initial activity on flies, with varying levels of residual protection against fruit infestation. An organic pyrethrum insecticide was not effective, whereas the neonicotinoid insecticide acetamiprid was found to have activity for up to five days. Rainfall after application greatly reduced the level of control achieved by some insecticides. Field-scale evaluation of conventional and organic spray programs initiated in response to capture of D. suzukii flies in monitoring traps indicated that both types of management provide significant fruit protection compared to untreated fields, with less larval detection in the conventionally-produced berries. •Insecticides have varying residual activity against Drosophila suzukii.•Control of D. suzukii is negatively affected by rainfall.•Conventional and organic spray programs in blueberry provide control of D. suzukii.