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Wielders, J.P.M.; Porpiglia, N.M.; Schellenberg, F.; Deenmamode, J.; Delanghe, J.; Anton, R.F.; Bortolotti, F.; Siebelder, C.; Tagliaro, F.; Weykamp, C.; Helander, A.
Clinica chimica acta, 03/2024, Letnik: 555Journal Article
•IFCC position paper about CDT outlining caveats, key points, and recommendations.•Alcohol intake versus CDT is discussed as well as the cut-off and expected range.•Comparison studies using inadequate study populations will lead to wrong outcome.•Standardisation has led to test accuracy improvements in national EQAS. Carbohydrate deficient transferrin (CDT) is a biomarker for excessive alcohol consumption utilized in clinical and forensic medicine and workplace testing. Previously, many different analytical methods for CDT were used and the measurand varied considerably, making direct comparison of test results difficult. To end this confusion, the IFCC established a working group on CDT standardisation (WG-CDT) which completed its tasks in 2017. This IFCC position paper by the WG-CDT summarizes state of the art information about the measurand and the analytical methods and gives concise recommendations for its utilization. The results achieved by the CDT standardisation process led to accuracy improvements in national external quality assessment schemes over the years. A brief review of ROC based comparison studies with the traditional biomarkers (GGT, MCV, ALT and AST) discusses the bias resulting from inadequate study populations. In large groups of the general population the superior diagnostic performance of CDT is confirmed. The relationship between alcohol intake versus resulting CDT is discussed as well as the cutoff and measurement uncertainty. Concerning the application in practice, potential pitfalls are considered and recommendations handling both analytical and preanalytical caveats are given. Finally, some examples of serious misunderstandings in publications about CDT are addressed.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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