Just as people living in the early 1900s experienced the horrors of World War I followed by the Spanish influenza epidemic, those of us surviving the coronavirus disease 2019 pandemic will have our lives forever changed. Both pandemics defied the capabilities of prevailing healthcare and public health. Since there was no known cure in either pandemic, much depended on nurses to fight the battle against the viruses. History has shown pandemics are occurring more frequently and are unpredictable in timing and severity. Therefore, we need to place focus on the valuable lessons from the century's two pandemics to prepare for future global disease outbreaks. Lessons that will benefit nursing are the importance of continual preparation and planning, care coordination across communities and healthcare systems, and ensuring nurses have the necessary resources and training to perform their roles in an effective and safe manner.