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Zeng, Liang; Ren, Hua-Zhan; Lv, Gui-Fen; Ouyang, Xuan-Hui; He, De-Liang; Li, Jin-Heng
Organic letters, 03/2024, Letnik: 26, Številka: 12Journal Article
An iodoarene-driven electroreductive remote C(sp3)–H arylation of unsymmetrical 1-(o-iodoaryl)alkyl ethers with cyanoarenes for the site selective synthesis of α-(hetero)aryl ethers is developed. With the introduction of cyanoarenes as both aryl sources and electron transfer mediators, this method includes an iodoarene-driven strategy to enable the regiocontrollable formation of two new bonds, one C(sp2)–H bond, and one C(sp2)–C(sp3) bond, in a single reaction step through the sequence of halogen atom transfer (XAT), hydrogen atom transfer (HAT), radical–radical coupling, and decyanation.
