Ineffective workplace relationships and an inconducive workplace culture contribute to poor job satisfaction and high nurse educator turnover rates. The aim of the study was to implement a program to transform the workplace culture towards person-centeredness in a public nursing education institution in South Africa. The study followed a Transformative Practice Development design using a participatory action research approach. The Transformative Practice Development method guided a program implemented from February 2019 to November 2019 to promote a person-centered workplace culture. From a population of nurse educators and nurse managers, we purposively sampled 46 participants. Baseline data were collected during consensus meetings in February and May 2019 facilitated by two independent nursing education experts. Twelve feedback sessions were conducted to obtain feedback during program implementation. Data were thematically analyzed. During implementation, the program addressed positive work relations, communication and leadership. The participants indicated that the program facilitated person-centered work relations through group cohesion, change processes, and real and authentic attitudes. Person-centered communication is achieved through reflective communication and cultural sensitivity. Nurse educators should enhance their leadership styles by evaluating and transforming their leadership traits and processes to person-centeredness.