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Antônio, Luana Grupioni Lourenço; Freitas-Lima, Priscila; Pereira-da-Silva, Gabriela; Assirati, João Alberto; Matias, Caio Marconato; Cirino, Mucio Luiz Assis; Tirapelli, Luis Fernando; Velasco, Tonicarlo Rodrigues; Sakamoto, Americo Ceiki; Carlotti, Carlos Gilberto; Tirapelli, Daniela Pretti da Cunha
Journal of molecular neuroscience, 12/2019, Letnik: 69, Številka: 4Journal Article
The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. Hippocampus and blood samples were collected from 20 patients with MTLE-HS, ten of whom had a favorable surgical outcome (Engel I) and ten with an unfavorable surgical outcome (Engel III-IV). Hippocampus samples from autopsied individuals with no neurological or psychiatric medical history (necropsy samples) and blood samples from healthy individuals were used as controls. Real-time quantitative PCR (RQ-PCR) was used to analyze miRNA expression. The results showed that the expressions of these miRNAs differed quantitatively in the hippocampus and blood of patients with MTLE-HS in comparison to the respective control. This difference was most pronounced for miR-145, which was hypo-expressed in the hippocampus and hyper-expressed in the blood of MTLE-HS patients. MiRNAs miR-145, miR-181c, miR-199a and miR-1183 were hyper-expressed in the blood of patients with MTLE-HS. No statistical differences in the levels of these miRNAs in the blood or hippocampus were found between Engel I patients and Engel III-IV patients. These results suggest that the analyzed microRNAs are potential circulating biomarkers for epilepsy diagnosis.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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