E-viri
Recenzirano
-
Dihal, Ashwin A.; Woutersen, Ruud A.; Ommen, Ben van; Rietjens, Ivonne M.C.M.; Stierum, Rob H.
Cancer letters, 07/2006, Letnik: 238, Številka: 2Journal Article
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001< P<0.05). During differentiation Caco-2 cells formed 5 phase II metabolites, of which the amount of 4′- O-methyl-quercetin-3′- O-glucuronide correlated with the differentiation grade ( r=0.99, P<0.003). The increment of cell proliferation at low quercetin concentrations and the decrease in cell differentiation are effects opposite to what would be expected for a functional food ingredient with anti-carcinogenic potential.
