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Kang, Baeki E.; Choi, Jun‐Yong; Stein, Sokrates; Ryu, Dongryeol
European journal of clinical investigation, October 2020, 2020-10-00, 20201001, Letnik: 50, Številka: 10Journal Article
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite in energy metabolism as well as a co‐substrate in biochemical reactions such as protein deacylation, protein ADP‐ribosylation and cyclic ADP‐ribose synthesis mediated by sirtuins, poly (ADP‐ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD+ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD+. The therapeutic potential of dietarily available NAD+ boosters preserving the NAD+ pool has been attracting attention after the discovery of declining NAD+ levels in ageing model organisms as well as in several age‐related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD+, including the salubrious effects of NAD+ boosters and discuss their future translational strategies.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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