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STEELE, Jonathan C. P.; VEITCH, Nigel C.; KITE, Geoffrey C.; SIMMONDS, Monique S. J.; WARHURST, David C.
Journal of natural products (Washington, D.C.), 01/2002, Letnik: 65, Številka: 1Journal Article
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
