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Reynolds, Catherine J; Pade, Corinna; Gibbons, Joseph M; Lin, Kai-Min; Muñoz Sandoval, Diana; Pieper, Franziska P; Joy, George; Forooghi, Nasim; Treibel, Thomas A; Manisty, Charlotte; Moon, James C; Semper, Amanda; Brooks, Tim; McKnight, Áine; Abbass, Hakam; Abiodun, Aderonke; Alldis, Zoe; Amin, Oliver E; Andiapen, Mervyn; Augusto, João B; Baca, Georgina L; Bhuva, Anish N; Boulter, Alex; Boyton, Rosemary J; O'Brien, Ben; Bullock, Natalie; Captur, Gabriella; Champion, Nicola; Coleman, Tom; Couto-Parada, Xose; Cutino-Moguel, Teresa; D'Arcangelo, Silvia; Douglas, Brooke; Di Genova, Cecilia; Dieobi-Anene, Keenan; Diniz, Mariana O; Finlay, Malcolm; Forooghi, Nasim; Gibbons, Joseph M; Gilroy, Derek; Harker, Gabrielle; Hemingway, Georgia; Hewson, Jacqueline; Heywood, Wendy; Hickling, Lauren M; Howes, Lee; Itua, Ivie; Lee, Wing-Yiu Jason; Jensen, Melaniepetra; Jones, Jessica; Joy, George; Kurdi, Hibba; Lambourne, Jonathan; Liu, Siyi; Maini, Mala K; Mandadapu, Vineela; Manisty, Charlotte; McKnight, Áine; Menacho, Katia; Millward, Sebastian; Mitchelmore, Oliver; Moon, Christopher; Muñoz Sandoval, Diana; Murray, Sam M; Otter, Ashley; Pade, Corinna; Palma, Susana; Parker, Ruth; Patel, Kush; Pawarova, Mihaela; Piniera, Brian; Pieper, Franziska P; Rannigan, Lisa; Rapala, Alicja; Reynolds, Catherine J; Robathan, Matthew; Rosenheim, Joshua; Rowe, Cathy; Royds, Matthew; Sackville West, Jane; Sambile, Genine; Selman, Hannah; Semper, Amanda; Seraphim, Andreas; Simion, Mihaela; Sugimoto, Michelle; Swadling, Leo; Taylor, Stephen; Thomas, Stephen; Treibel, Thomas A; Tucker, Art; Varghese, Ann; Veerapen, Jessry; Vijayakumar, Mohit; Warner, Tim; Welch, Sophie; White, Hannah; Wodehouse, Theresa; Wynne, Lucinda; Chain, Benjamin
Science, 07/2022, Letnik: 377, Številka: 6603Journal Article
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
