E-viri
Recenzirano
Odprti dostop
-
Laursen, Nick S; Friesen, Robert H E; Zhu, Xueyong; Jongeneelen, Mandy; Blokland, Sven; Vermond, Jan; van Eijgen, Alida; Tang, Chan; van Diepen, Harry; Obmolova, Galina; van der Neut Kolfschoten, Marijn; Zuijdgeest, David; Straetemans, Roel; Hoffman, Ryan M B; Nieusma, Travis; Pallesen, Jesper; Turner, Hannah L; Bernard, Steffen M; Ward, Andrew B; Luo, Jinquan; Poon, Leo L M; Tretiakova, Anna P; Wilson, James M; Limberis, Maria P; Vogels, Ronald; Brandenburg, Boerries; Kolkman, Joost A; Wilson, Ian A
Science, 11/2018, Letnik: 362, Številka: 6414Journal Article
Broadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle electron microscopy structures of these antibodies with hemagglutinins from influenza A and B viruses reveal binding to highly conserved epitopes. Collectively, our findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency. In combination with adeno-associated virus-mediated gene delivery, they may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.