E-viri
Recenzirano
-
LOU, Cheuk K; BAYLY, Christopher I; QINGPING WANG; SKOREY, Kathryn; WADDLETON, Deena; PAYETTE, Paul; RAMACHANDRAN, Chidambaram; KENNEDY, Brian P; SCAPIN, Giovana; GAUTHIER, Jacques Yves; CHUN SING LI; THERIEN, Michel; ASANTE-APPIAH, Ernest; CROMLISH, Wanda; BOIE, Yves; FORGHANI, Farnaz; DESMARAIS, Sylvie
Bioorganic & medicinal chemistry letters, 02/2004, Letnik: 14, Številka: 4Journal Article
A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.
