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Hjorth-Hansen, H; Stentoft, J; Richter, J; Koskenvesa, P; Höglund, M; Dreimane, A; Porkka, K; Gedde-Dahl, T; Gjertsen, B T; Gruber, F X; Stenke, L; Eriksson, K M; Markevärn, B; Lübking, A; Vestergaard, H; Udby, L; Bjerrum, O W; Persson, I; Mustjoki, S; Olsson-Strömberg, U
Leukemia, 09/2016, Letnik: 30, Številka: 9Journal Article
Dasatinib (DAS) and interferon-α have antileukemic and immunostimulatory effects and induce deep responses in chronic myeloid leukemia (CML). We assigned 40 newly diagnosed chronic-phase CML patients to receive DAS 100 mg o.d. followed by addition of pegylated interferon-α2b (PegIFN) after 3 months (M3). The starting dose of PegIFN was 15 μg/week and it increased to 25 μg/week at M6 until M15. The combination was well tolerated with manageable toxicity. Of the patients, 84% remained on PegIFN at M12 and 91% (DAS) and 73% (PegIFN) of assigned dose was given. Only one patient had a pleural effusion during first year, and three more during the second year. After introduction of PegIFN we observed a steep increase in response rates. Major molecular response was achieved in 10%, 57%, 84% and 89% of patients at M3, M6, M12 and M18, respectively. At M12, MR(4) was achieved by 46% and MR(4.5) by 27% of patients. No patients progressed to advanced phase. In conclusion, the combination treatment appeared safe with very promising efficacy. A randomized comparison of DAS±PegIFN is warranted.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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