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Minard, Aisling; Morgan, Danielle; Raguseo, Federica; Di Porzio, Anna; Liano, Denise; Jamieson, Andrew G; Di Antonio, Marco
Chemical communications (Cambridge, England), 08/2020, Letnik: 56, Številka: 63Journal Article
G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.
