Abstract In this article, we focus on studying the nexus between moisture transport deficit and drought occurrence in nine key regions across the world where the magnitude of meteorological drought is projected to increase from 1850 to 2100 under a high anthropogenic emission scenario. These regions are central America, southwestern South America, northern Brazil, the Amazon, northeastern Brazil, the western Mediterranean, southern Africa, the eastern Mediterranean, and southwestern Australia. Using the Lagrangian particle dispersion model FLEXPART, we identify the specific moisture sources of the regions (the own region, the nearby continental source and the oceanic sources) and obtain their contributions to the precipitation in the regions for the period 1980–2018. For each region and specific moisture source, the conditional probability of meteorological drought occurrence given an equivalent contribution deficit from the source is estimated using copula models, a statistical methodology that allows us to capture complex relationships between variables. We identify the dominant moisture source in each region, which is the source for which the contribution deficit maximises drought probability. A variety of cases are found: in three regions, the dominant source is the region itself, in one region, it is the nearby terrestrial source, and in five regions, it is an oceanic source. In general, contribution deficits from specific moisture sources are associated with only slightly greater drought probabilities than those from major global moisture sources. We also reveal that the source that contributes the most to precipitation in a given region is not necessarily the dominant source of drought in the region. These results highlight the importance of understanding the role of dominant moisture sources and moisture transport deficits on meteorological drought occurrence at a regional scale.