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  • The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation
    Berry, Gerald J; Burke, Margaret M; Andersen, Claus; Bruneval, Patrick; Fedrigo, Marny; Fishbein, Michael C; Goddard, Martin; Hammond, Elizabeth H; Leone, Ornella; Marboe, Charles; Miller, Dylan; Neil, Desley; Rassl, Doris; Revelo, Monica P; Rice, Alexandra; Rene Rodriguez, E; Stewart, Susan; Tan, Carmela D; Winters, Gayle L; West, Lori; Mehra, Mandeep R; Angelini, Annalisa

    The Journal of heart and lung transplantation, 12/2013, Letnik: 32, Številka: 12
    Journal Article

    During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.

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