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  • Valitutti, Francesco; Leonard, Maureen M; Kenyon, Victoria; Montuori, Monica; Piemontese, Pasqua; Francavilla, Ruggiero; Malamisura, Basilio; Norsa, Lorenzo; Calvi, Angela; Lionetti, Maria Elena; Baldassarre, Mariella; Trovato, Chiara Maria; Perrone, Michela; Passaro, Tiziana; Sansotta, Naire; Crocco, Marco; Morelli, Annalisa; Raguseo, Lidia Celeste; Malerba, Federica; Elli, Luca; Cristofori, Fernanda; Catassi, Carlo; Fasano, Alessio

    The American journal of gastroenterology, 03/2023, Letnik: 118, Številka: 3
    Journal Article

    The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.