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Zeydan, Burcu; Gu, Xinyi; Atkinson, Elizabeth J; Keegan, B Mark; Weinshenker, Brian G; Tillema, Jan-Mendelt; Pelletier, Daniel; Azevedo, Christina J; Lebrun-Frenay, Christine; Siva, Aksel; Okuda, Darin T; Kantarci, Kejal; Kantarci, Orhun H
Neurology : neuroimmunology & neuroinflammation, 2018-March, Letnik: 5, Številka: 2Journal Article
OBJECTIVETo assess whether cervical spinal cord atrophy heralds the onset of progressive MS. METHODSWe studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm) of axial T2-weighted images between C2 and C7 landmarks. The midsagittal T2-weighted image from the end of C2 to the end of C7 vertebra was used to measure the cervical spine (c-spine) length (mm). Sex, age at cervical MRI, number and location of cervical spinal cord lesions, c-spine length, and diagnoses were analyzed against the outcome measures of CASA and C2 and C7 slice segmental areas. RESULTSIntrarater and interrater agreement was excellent (intraclass correlation coefficient >0.97). The CASA area (p = 0.03) and C7 area (p = 0.002) were smaller in SPMS compared with RRMS. The C2 area (p = 0.027), CASA (p = 0.004), and C7 area (p = 0.003) were smaller in SPMS compared with RIS. The C2 area did not differ between SPMS and RRMS (p = 0.09). The C2 area (p = 0.349), CASA (p = 0.136), and C7 area (p = 0.228) did not differ between RIS and MS (SPMS and RRMS combined). In the multivariable model, ≥2 cervical spinal cord lesions were associated with the C2 area (p = 0.008), CASA (p = 0.009), and C7 area independent of disease course (p = 0.017). Progressive disease course was associated with the C7 area independent of the cervical spinal cord lesion number (p = 0.004). CONCLUSIONCervical spinal cord atrophy is evident at the onset of progressive MS and seems partially independent of the number of cervical spinal cord lesions. CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that MRI cervical spinal cord atrophy distinguishes patients at the onset of progressive MS from those with RIS and RRMS.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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