Trouble seems to be characteristic of contemporary politics and life. From the environment to the pandemic, crises of political credibility around the world, conflict on social media and the drama of so-called “cancel culture”, avoiding or settling trouble seems more unimaginable than ever. Yet, as the theme of this conference makes clear, trouble is not always negative, especially when posed in verb form. To trouble preconceptions, orthodoxies or alienating norms can be productive, exciting and transformative. This is as much the case in research as in any other area of life. Troubling our founding assumptions, our research questions, our theories and methods is the way we move forward, even if it is not always easy or immediately rewarding. In this keynote presentation I will reflect on my own engagements with forms of scholarly trouble, drawing on the work of Donna Haraway in her book Staying with the trouble (2018) to identify key ways in which we as researchers may “embrace trouble” in useful and productive ways. Thinking through some central propositions articulated by Haraway in her engagement with other scholars, such as the importance of storytelling, the value of grieving, and the uses of response-ability, I will offer a range of examples drawn from my own work in critical drug studies and ontopolitical research to highlight the promises and pitfalls of trouble. In doing so, I aim to acknowledge the opportunities I have enjoyed over the years to be part of the innovative and courageous field of critical drug studies, of which the Contemporary Drug Problems conference is also an important part.