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Elias, George; Meysman, Pieter; Bartholomeus, Esther; De Neuter, Nicolas; Keersmaekers, Nina; Suls, Arvid; Jansens, Hilde; Souquette, Aisha; De Reu, Hans; Emonds, Marie-Paule; Smits, Evelien; Lion, Eva; Thomas, Paul G; Mortier, Geert; Van Damme, Pierre; Beutels, Philippe; Laukens, Kris; Van Tendeloo, Viggo; Ogunjimi, Benson
eLife, 01/2022, Letnik: 11Journal Article
Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells. However, antigen-specific memory CD4 T cells exist in unexposed antigen-naïve hosts. In this study, we use high-throughput sequencing of memory CD4 TCRβ repertoire and machine learning to show that individuals with preexisting vaccine-reactive memory CD4 T cell clonotypes elicited earlier and higher antibody titers and mounted a more robust CD4 T cell response to hepatitis B vaccine. In addition, integration of TCRβ sequence patterns into a hepatitis B epitope-specific annotation model can predict which individuals will have an early and more vigorous vaccine-elicited immunity. Thus, the presence of preexisting memory T cell clonotypes has a significant impact on immunity and can be used to predict immune responses to vaccination.
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in: SICRIS
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