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Mrozik, Helmut; Bochis, Richard J; Eskola, Philip; Matzuk, Alexander; Waksmunski, Frank S; Olen, Leonard E; Schwartzkopf, George; Grodski, Alex; Linn, Bruce O
Journal of medicinal chemistry, 09/1977, Letnik: 20, Številka: 9Journal Article
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.
