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Zhang, Zhen-Jia; Gao, Qiang; Fang, Xiao-Dong; Ding, Zhi-Hang; Gao, Dong-Min; Xu, Wen-Ya; Cao, Qing; Qiao, Ji-Hui; Yang, Yi-Zhou; Han, Chenggui; Wang, Ying; Yuan, Xuefeng; Li, Dawei; Wang, Xian-Bing
eLife, 03/2020, Letnik: 9Journal Article
Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood. Here, we characterized a pro-viral role of CCR4 in replication of a plant cytorhabdovirus (BYSMV). The barley ( ) CCR4 protein (HvCCR4) was identified to interact with the BYSMV phosphoprotein (P). The BYSMV P protein recruited HvCCR4 from processing bodies (PBs) into viroplasm-like bodies. Overexpression of HvCCR4 promoted BYSMV replication in plants. Conversely, knockdown of the small brown planthopper CCR4 inhibited viral accumulation in the insect vector. Biochemistry experiments revealed that HvCCR4 was recruited into N-RNA complexes by the BYSMV P protein and triggered turnover of N-bound cellular mRNAs, thereby releasing RNA-free N protein to bind viral genomic RNA for optimal viral replication. Our results demonstrate that the co-opted CCR4-mediated RNA decay facilitates cytorhabdovirus replication in plants and insects.
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in: SICRIS
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