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Zhou, Xian‐Yang; Li, Ling‐Xin; Zhang, Zhen; Duan, Shi‐Chao; Huang, Ying‐Wen; Luo, Yi‐Yang; Mu, Xiao‐Dong; Chen, Zhi‐Wei; Qin, Yong; Hu, Jing; Yin, Jian; Yang, Jin‐Song
Angewandte Chemie International Edition, July 18, 2022, Letnik: 61, Številka: 29Journal Article
Acinetobacter baumannii is currently posing a serious threat to global health. Lipopolysaccharide (LPS) is a potent virulence factor of pathogenic Gram‐negative bacteria. To explore the antigenic properties of A. baumannii LPS, four Kdo‐containing inner core glycans from A. baumannii strain ATCC 17904 were synthesized. A flexible and divergent method based on the use of the orthogonally substituted α‐Kdo‐(2→5)‐Kdo disaccharides was developed. Selective removal of different protecting groups in these key precursors and elongation of sugar chain via α‐stereocontrolled coupling with 5,7‐O‐di‐tert‐butylsilylene or 5‐O‐benzoyl protected Kdo thioglycosides and 2‐azido‐2‐deoxyglucosyl thioglycoside allowed efficient assembly of the target molecules. Glycan microarray analysis of sera from infected patients revealed that the 4,5‐branched Kdo trimer was a potential antigenic epitope, which is attractive for further immunological research to develop carbohydrate vaccines against A. baumannii. Four inner core oligosaccharides from the lipopolysaccharide (LPS) of A. baumannii strain ATCC 17904 were chemically synthesized (see structures). Antigenic investigation indicated that the 4,5‐branched Kdo trisaccharide, a common inner core structure of A. baumannii LPS, is a potential antigenic epitope that could be used for further immunological research to develop diagnostic tools or vaccines against A. baumannii.
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