Keeping output stable is necessary for solar organic rankine cycle (SORC) considering variable solar irradiation conditions. In this study, zeotropic mixtures are introduced into SORC with stable output. Evaporation pressure and turbine inlet temperature are optimized with the overall system efficiency as optimization objective. Comparisons are drawn between the basic SORC and regenerative SORC. The influences of zeotropic mixture composition on the overall system efficiency, ORC efficiency, heat source outlet temperature, mass flow rate of heat source and working fluids and temperature rise of internal heat exchanger (IHE) are analyzed. The results show that zeotropic mixtures can slightly increase the overall system efficiency of the basic SORC system compared with the optimal pure working fluid system, but for the regenerative SORC system, the optimal overall system efficiency is higher when pure cyclohexane is used. When cyclopentane mole fraction is 0.4, the overall system efficiency of the basic SORC system reaches maximal value of 16.08%, which is 0.12% higher than for the optimal pure working fluids system, relatively. Under the optimum conditions, the optimal overall system efficiency of the regenerative SORC system is 52.11% higher than that of the basic SORC system.