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  • Eosinophilic myocarditis: a...
    Ammirati, Enrico, Dr; Stucchi, Miriam, MD; Brambatti, Michela, MD; Spanò, Francesca, MD; Bonacina, Edgardo, MD; Recalcati, Fabio, MD; Cerea, Giulio, MD; Vanzulli, Angelo, MD; Frigerio, Maria, MD; Oliva, Fabrizio, MD

    The Lancet (British edition), 06/2015, Letnik: 385, Številka: 9986
    Journal Article

    Eosinophilic myocarditis is a rare form of myocardial inflammation, a life-threating condition with a variable presentation1 characterised by eosinophilic infiltration of the myocardium, associated with systemic disorders such as parasitic infection, hypersensitivity reaction to drugs, eosinophilic granulomatosis with polyangiitis, hyper-eosinophilic syndrome, and malignancy.2 Eosinophilic myocarditis as a paraneoplastic occurrence is very rare.2 The pathogenesis is unclear; one explanation might be bone marrow stimulation via interleukin-5 (IL-5) secreted by the tumour itself, associated with peripheral hypereosinophilia. Cardiac symptoms, raised cardiac enzymes, and severe cardiac dysfunction despite normal coronary angiography pointed to the diagnosis, but the enlarged right ventricle and absence of peripheral hypereosinophilia were unusual.4 We established definitive diagnosis on the basis of endomyocardial biopsy and started steroids early, which helped to restore cardiac contractility and enabled her to start chemotherapy.