Fermented dry sausages (FDS) without nitrite added, fortified with bioactive phenol and flavonoid compounds originating from the ethanol extract of Kitaibelia vitifolia were food matrix for investigation of its antioxidant and antimicrobial potency. These activities were researched in order to improve the sausages' shelf-life, safety, and provide health benefits to consumers as well. The oxidative stability of the FDS, containing two different levels of natural preservative, was evaluated using five different contemporary methods for antioxidative activity. The activity was tested on the 20th day of the refrigerated storage. Minimum inhibitory concentrations of the sausage extract were determined against six microorganisms, using a micro dilution method. Determined optimal effective concentration of dissolved K. vitifolia extract (12.5g/kg of meat dough) revealed strong antioxidant activity, and moderate antimicrobial activity against Escherichia coli (minimum inhibitory concentrations=15.625μg/mL). The modified sausages had typical chemical–physical characteristics of FDS, controlled on 0, 13, 26d of ripening and 20, 40 and 60d of storage. •Produced healthier fermented dry sausage (FDS) that no nitrites are added•FDS fortified by bioactive phenol and flavonoid compounds from Kitaibelia vitifolia•Significant increase of oxidative stability in fortified food matrix of FDS•Great antimicrobial activity of fortified sausage, highest against E. coli•Optimal effective concentration of herb extract was 12.5g/kg of meat dough.