The now famous virgin headspace experiment from late Braja D. Mookherjee and Subha Patel, and its use in the creation of scent ‘Virgin N° 1’ by Christophe Laudamiel and Christoph Hornetz for the novel by Patrick Süskind, and the movie by Tom Tykwer ‘Perfume – The Story of a Murderer’ (Constantin Film – Thierry Mugler Parfums – IFF, 2006) is discussed. Another fragrance from the luxury coffret, ‘Salon Rouge’, is described as well, illustrating how molecules and natural ingredients can be utilized, not only to create innovative or artistic fragrance compositions, but also to provide fundamental consumer education, improving the public image both of Chemistry and Perfumery.