E-viri
Recenzirano
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Xie, Ya‐Ping; Wang, Yuan; Zhang, Kai; Liu, Qing‐Mei; Yan, Qing‐Xiang; Zou, Zheng‐Biao; Xu, Yan‐Qin; Liu, Guang‐Ming; Huang, Xiao‐Fang; Yang, Xian‐Wen
European journal of organic chemistry, February 5, 2024, Letnik: 27, Številka: 5Journal Article
Three new sesquiterpene‐hydroquinone hybrids, saromacrophorins A–C (1–3) were isolated from the deep‐sea‐derived fungus Sarocladium terricola 494a, along with nine known compounds. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Noteworthily, compound 1 is a rare 5′,6′‐dihydroxymacrophorin and compound 3 is the first example of macrophorin possessing 4′S‐configuration. Compound 4 showed potent anti‐food allergic activity with an IC50 value of 18.9 μM. Saromacrophorin A, a macrophorin cotanied rare 5′,6′‐dihydroxylisoepiepoformin fragment; saromacrophorin C, the first example of 4′S‐macrophorin; macrophorin D, anti‐food allergic activity with IC50 value of 18.9 μM.
