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Dai, Liqun; Liu, Jie; Zhao, Xiaosheng; Li, Yuhao; Zhou, Siming; Yuan, Liping; Shu, Diyun; Pan, Lili; Liu, Yuan‐hao; Qian, Zhiyong
Advanced functional materials, 06/2023, Letnik: 33, Številka: 23Journal Article
Boron neutron capture therapy (BNCT) is a promising therapy for refractory cancer based on the cytotoxic reaction of 10B (n, α) 7Li. Although two BNCT agents are clinically available, they are quickly metabolized and show modest enrichment in tumor sites, partially limiting BNCT widespread application. Consequently, novel agents that perform active targeting and show good biocompatibility have to be developed. Herein, boronophenylalanine‐containing polydopamine (B‐PDA) nanoparticles are easily fabricated by encapsulating boronophenylalanine (BPA) in polydopamine via nitrogen‐boronate coordination. In this study, B‐PDA achieves increased tumor accumulation and prolonged retention effects in the tumor site and superior antitumor activity post neutron irradiation in the orthotopic xenograft glioma model. In brief, this study offers a novel strategy for BPA delivery and may broaden the perspective on nanomedicine design for BNCT. The boronophenylalanine‐containing polydopamine (B‐PDA) nanoparticles developed in this study are a promising and favorable candidate for boron neutron capture therapy (BNCT) against glioma, which achieve sufficient tumor accumulation and retention for neutron irradiation. After irradiation, BNCT largely induced DNA double‐strand breaks to produce excellent antitumor effects. The B‐PDA nanoparticles are potential to be used for BNCT against glioma.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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