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  • Can 3.0 Tesla diffusion ten...
    Ozal, Safiye Tokgoz; Inci, Ercan; Gemici, Aysegul Akdogan; Turgut, Hurriyet; Cikot, Murat; Karabulut, Mehmet

    Clinical imaging, September-October 2018, 2018 Sep - Oct, 2018-09-00, 20180901, Letnik: 51
    Journal Article

    To investigate the relationship between diffusion tensor imaging (DTI) parameters such as fractional anisotropy (FA), mean diffusivity (MD), relative anisotropy (RA), and volume ratio (VR) values, and prognostic factors of invasive breast cancer. This retrospective study examined 63 patients with pathologically confirmed invasive breast cancers. The patients underwent pre-operative diffusion-weighted magnetic resonance imaging (MRI) at 3.0 Tesla. The relationship between DTI parameters and tumor size, histologic and nuclear grade, axillary lymph node status, lymphovascular and perineural invasion status, estrogen receptor (ER), progesterone receptor (PR), CERB-B2, and Ki-67 were analyzed. Patients with lymph node metastasis (p = 0.018; p < 0.05) and/or lymphovascular invasion (p = 0.001; p < 0.01) and/or histologic grade 3 tumors (p < 0.05) had statistically significantly low MD values. There was a statistically significant relationship between ER and MD (r = 0.452, p < 0.01), PR and MD (p = 0.001, p < 0.01); CERB-B2 and RA (p = 0.047, p < 0.05); Ki-67 and RA (p = 0.026; p < 0.05); Ki-67 and VR (p = 0.021; p < 0.05); and lymphovascular invasion and FA (p = 0.045, p < 0.05) values. DTI parameters of malignant masses in breast cancer patients correlate with tumor size, lymph node status, histologic grade, lymphovascular invasion, Ki-67, CERB B2, ER, and PR. •Diffusion tensor imaging (DTI) can provide valuable information on tissue microstructure and pathophysiology.•Malignant tumors with high cellularity exhibit low ADC values due to their inverse relationship with tumor cellularity.•DTI parameters of breast cancer tumors correlate with tumor size, lymph node status, histologic grade, lymphovascular invasion, Ki-67, CERB B2, ER, and PR