Social media influencers are increasingly recognized for their ability to influence tourists' decision-making processes. The emergent phenomenon of virtual influencers presents an unprecedented challenge to their human counterparts, reshaping the dynamics of the tourism industry. It remains a challenge to integrate various forms of destination advertising and harmonize the approaches of both human and virtual influencers to effectively attract tourists. This study addresses this gap by investigating the effectiveness of human and virtual influencers in endorsing natural versus cultural destinations. Adopting source credibility theory, we conduct five empirical studies. Our findings reveal that virtual influencers boost visit intentions for cultural destinations, while human influencers do so for natural destinations. Credibility and self-referencing play a serially mediating role in this process. Furthermore, this study explores the moderating role of tourists’ preference for uniqueness. This research offers valuable insights for tourism industry managers aiming to harness the power of virtual influencers effectively.