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Halasi, Marianna; Gartel, Andrei L.
Cell cycle (Georgetown, Tex.), 6/15/2009, 2009/06/15, 2009-Jun-15, 2009-06-15, 20090615, Letnik: 8, Številka: 12Journal Article
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.
