•We analyse multiaxial fatigue.•We compare time domain classical criteria with their translation into frequency domain.•We demonstrate the goodness of the frequency domain approach also in multiaxial stress state conditions. Fatigue analysis of mechanical components subjected to random loads has been recently upgraded through several developments of calculation procedures, with the scope to support the designer within the loading condition numerical simulation. Under such scenario, the frequency domain approach is characterized by interesting features, which support its adoption in alternative or in conjunction with the classic time-domain approach, especially when the frequency domain is applied for the individuation of the component critical locations. The major goal of this paper consists of an overview about the strength and weaknesses of frequency approach with respect to the time domain one by comparing the reference time domain methods with their frequency domain translation. A significant test case development will be shown, representing a classic automotive one (chassis validation). Promising results of the frequency method application will be presented, encouraging its adoption on large scale.