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Menasché, Philippe; Hagège, Albert A; Scorsin, Marcio; Pouzet, Bruno; Desnos, Michel; Duboc, Denis; Schwartz, Ketty; Vilquin, Jean-Thomas; Marolleau, Jean-Pierre
The Lancet (British edition), 01/2001, Letnik: 357, Številka: 9252Journal Article
Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic heart failure. We implanted autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas. 5 months later, there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography. Although this result is encouraging, it requires validation by additional studies.
