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Vardon-Bounes, Fanny; Ruiz, Stéphanie; Gratacap, Marie-Pierre; Garcia, Cédric; Payrastre, Bernard; Minville, Vincent
International journal of molecular sciences, 07/2019, Letnik: 20, Številka: 14Journal Article
Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.
