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  • A novel t(2;17) in transfor...
    Lazarevic̀, Vladimir Lj; Tomin, Dragica; Jankovic̀, Gradimir M.; Antic̀, Darko; Denčic̀, Marija; Gotic, Mirjana; Boškovic̀, Darinka

    Cancer genetics and cytogenetics, 2004, 2004-Jan-01, 2004-1-00, 20040101, Letnik: 148, Številka: 1
    Journal Article

    A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%–4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.