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Kallemeijn, Wouter W.; Li, Kah-Yee; Witte, Martin D.; Marques, André R. A.; Aten, Jan; Scheij, Saskia; Jiang, Jianbing; Willems, Lianne I.; Voorn-Brouwer, Tineke M.; van Roomen, Cindy P. A. A.; Ottenhoff, Roelof; Boot, Rolf G.; van den Elst, Hans; Walvoort, Marthe T. C.; Florea, Bogdan I.; Codée, Jeroen D. C.; van der Marel, Gijsbert A.; Aerts, Johannes M. F. G.; Overkleeft, Herman S.
Angewandte Chemie, December 7, 2012, Letnik: 51, Številka: 50Journal Article
A high‐end label: Cyclophellitol aziridine‐type activity‐based probes allow for ultra‐sensitive visualization of mammalian β‐glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non‐mammalian β‐glucosidases (see picture). These probes offer new ways to study β‐exoglucosidases, and configurational isomers of the cyclophellitol aziridine core may give activity‐based probes targeting other retaining glycosidase families.
