Studies on Benzhydryl Derivatives. IV. Synthesis and Anti-inflammatory Activity of 2-O-(Diphenylacetyl)salicylic Acids

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Studies on Benzhydryl Derivatives. IV. Synthesis and Anti-inflammatory Activity of 2-O-(Diphenylacetyl)salicylic Acids

TAKEMURA, SHOJI; AZUMA, YOSHIKO; SHOGAKI, CHIYUKI; MIKI, YASUYOSHI; NAGATOMI, HIKARU; YASUI, BOMPEI; ANDO, KAZUKO

Chemical & pharmaceutical bulletin, 1983, Letnik: 31, Številka: 8

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A synthetic route to 2-O-(diphenylacetyl)salicylic acid derivatives was developed and the effects of the products on the heat-denaturation of albumin and on heat-induced erythrocytolysis were examined (in vitro anti-inflammation test). Trichloroethyl salicylate was acylated with diphenylacetic acid and its derivatives in the presence of methanesulfonyl chloride and pyridine, and the products were deprotected with zinc-acetic acid to give 2-O-(diphenylacetyl)salicylic acid derivatives. Their biological effects resembled those of ibuprofen.

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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.

Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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