•The eggplant peel is a rich source polyphenols with high antioxidant activity.•Were evaluated the effects of solvent, ultrasonic frequency, temperature and time.•All the parameters had a positive influence on polyphenols extraction.•The solvent concentration influenced negatively the anthocyanins extraction. The present study describes the extraction of total monomeric anthocyanin (TMA) and total phenolic content (TPC) from eggplant peel using ultrasonic treatments and methanol and 2-propanol as extraction solvents. The extraction yields were optimized by varying the solvent concentration, ultrasonic frequency, temperature and time of ultrasonic treatment. Box–Behnken design was used to investigate the effect of process variables on the ultrasound-assisted extraction. The results showed that for TPC extraction the optimal condition were obtained with a methanol concentration of 76.6%, 33.88kHz ultrasonic frequency, a temperature of 69.4°C and 57.5min extraction time. For TMA the optimal condition were the following: 54.4% methanol concentration, 37kHz, 55.1°C and process time of 44.85min.