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Xiao, Shuo; Coppeta, Jonathan R; Rogers, Hunter B; Isenberg, Brett C; Zhu, Jie; Olalekan, Susan A; McKinnon, Kelly E; Dokic, Danijela; Rashedi, Alexandra S; Haisenleder, Daniel J; Malpani, Saurabh S; Arnold-Murray, Chanel A; Chen, Kuanwei; Jiang, Mingyang; Bai, Lu; Nguyen, Catherine T; Zhang, Jiyang; Laronda, Monica M; Hope, Thomas J; Maniar, Kruti P; Pavone, Mary Ellen; Avram, Michael J; Sefton, Elizabeth C; Getsios, Spiro; Burdette, Joanna E; Kim, J Julie; Borenstein, Jeffrey T; Woodruff, Teresa K
Nature communications, 03/2017, Letnik: 8, Številka: 1Journal Article
The endocrine system dynamically controls tissue differentiation and homeostasis, but has not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic system supports murine ovarian follicles to produce the human 28-day menstrual cycle hormone profile, which controls human female reproductive tract and peripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (Solo-MFP, Duet-MFP and Quintet-MPF, respectively). These systems simulate the in vivo female reproductive tract and the endocrine loops between organ modules for the ovary, fallopian tube, uterus, cervix and liver, with a sustained circulating flow between all tissues. The reproductive tract tissues and peripheral organs integrated into a microfluidic platform, termed EVATAR, represents a powerful new in vitro tool that allows organ-organ integration of hormonal signalling as a phenocopy of menstrual cycle and pregnancy-like endocrine loops and has great potential to be used in drug discovery and toxicology studies.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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