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Ming, Hui; Zhang, Kunpeng; Ge, Shengbo; Shi, Yang; Du, Chunan; Guo, Xuqiang; Zhang, Libo
Nanomaterials (Basel, Switzerland), 01/2023, Letnik: 13, Številka: 2Journal Article
As a potential therapeutic agent, the clinical application of -nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
