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Schlebusch, Carina M.; Skoglund, Pontus; Sjödin, Per; Gattepaille, Lucie M.; Hernandez, Dena; Jay, Flora; Li, Sen; De Jongh, Michael; Singleton, Andrew; Blum, Michael G. B.; Soodyall, Himla; Jakobsson, Mattias
Science, 10/2012, Letnik: 338, Številka: 6105Journal Article
The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ~2.3 million single-nucleotide polymorphisms in 220 southern Africans and found that the Khoe-San diverged from other populations ≥100,000 years ago, but population structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response; potential adaptive introgression of protection from ultraviolet light; and selection predating modern human diversification, involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.
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in: SICRIS
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